Austin Pathology

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Alternate Names
Ordering Information

Aldosterone, renin concentration and their ratio (ARR) must be interpreted in the context of medications and electrolyte status.   For guidance on patient preparation, medications and result interpretation, click here  or contact Chemical Pathologist (03) 9496 5140.

For "upright" requests, collect blood mid-morning (9 - 10 am) from seated patients who have been upright (sitting, standing or walking) for 2 to 4 hours.  

For "supine" requests, the patient should be lying down for at least 6 hours.

This test cannot be "added on" to a previously collected sample

Cerner Test Name
MBS Number
EDTA (purple)
Collection Instruction
Collect at room temperature
Additional Collection Instructions

Aldosterone and Renin tests, if ordered together, can be collected in the same EDTA tube.

Please send to the laboratory immediately. EDTA plasma samples should be centrifuged in a non-refrigerated centrifuge; remove the EDTA plasma from the cells immediately after centrifugation.

If there is a delay and/or the sample is referred from another laboratory, please spin and separate the sample, store and transport frozen.

Minimum Adult Volume
Minimum Paediatric Volume

The Test Code for erect Aldosterone is ALDO

The Test Code for supine Aldosterone is ALDSUP

Once a week
Reference Interval

Upright Aldosterone concentration 

Supine Aldosterone concentration  

Aldosterone:Renin Ratio

< 70


Note Aldosterine:Renin ratio (ARR) for the purpose of screening for Primary Hyperaldosteronism: RI <70

An ARR >/= 70 should be repeated, taking into consideration any interferring medications. If positive again on the second occasion further investigation for Primary Hyperaldosteronism should be considered. It is important to understand that cut-off values may vary even between laboratories using the same testing method, depending on the patient population tested and the sensitivity/specificity desired. In general, lower cut-offs (e.g. around 30) will offer high sensitivity at the expense of specificity while higher cut-offs (e.g. 100) are more specific for primary hyperaldosteronism but may miss milder cases. Clinicians should be aware of the limitations of this cut-off.

Test Code
Container ID
Storage Instructions
Aliquot and freeze as soon as possible
Transport Instructions
Transport frozen
Laboratory Notes

Add ons: No add on testing to unseparated EDTA plasma.

If there happens to be unseparated EDTA plasma stored at 2-8 degrees Celcius, then test may be performed.