Austin Pathology

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Renin Concentration

Ordering Information

A record of dietary salt intake and/or administration of diuretics or vasodilator drugs should be made on the request form. 

Aldosterone, plasma renin concentrationand their ratio (ARR) must be interpreted in the context of medications and electrolyte status. For guidance on patient preparation, medications, and result interpretation, click here or contact Chemical Pathologist (03) 9496 5140

Add-on tests for Renin cannot be done on a previous sample which has been collected and/or stored at 4 Deg C.



EDTA (purple)
Collection Instruction
Collect at room temperature
Additional Collection Instructions


If specimens are collected from a location external to Austin Pathology, they should be spun and the plasma frozen at -70 or -80 degrees Celcius. Please note that freezing at -20 degrees is NOT sufficient and may cause cryo-activation of pro-renin leading to falsely high results.

Once frozen at -70 or -80 degrees, samples can be transferred to, or transported at, -20 degrees.

Minimum Adult Volume
Minimum Paediatric Volume

Renin and Aldosterone tests if ordered at the same time, can be collected into the same EDTA tube.

*Freezing at -20 degrees Celcius is NOT sufficient.

Once a week
Reference Interval

Spot Renin & Upright concentration 

4.4 - 46.1 mIU/L
Supine Renin concentration 2.8 - 39.9 mIU/L

Aldosterone:Renin Ratio

< 70


Note Aldosterine:Renin ratio (ARR) for the purpose of screening for Primary Hyperaldosteronism: RI <70

An ARR >/= 70 should be repeated, taking into consideration any interferring medications. If positive again on the second occasion further investigation for Primary Hyperaldosteronism should be considered. It is important to understand that cut-off values may vary even between laboratories using the same testing method, depending on the patient population tested and the sensitivity/specificity desired. In general, lower cut-offs (e.g. around 30) will offer high sensitivity at the expense of specificity while higher cut-offs (e.g. 100) are more specific for primary hyperaldosteronism but may miss milder cases. Clinicians should be aware of the limitations of this cut-off.

Test Code
Storage Instructions
Aliquot and freeze as soon as possible
Additional (Storage) Instructions

Spin and separate the plasma as soon as possible.

If the test is performed on the same day as collection, it can be kept at Room Temperature. If not, the plasma should be frozen at -70 or -80 degrees Celcius.

Transport Instructions
Transport frozen
Laboratory Notes

Add-on tests for Renin cannot be done on a previous sample which has been collected and/or stored at 4 Deg C.